![]() ![]() Best Practice & Research Clinical Gastroenterology. Colorectal cancer prevention in patients with ulcerative colitis. Lopez A., Pouillon L., Beaugerie L., Danese S., Peyrin-Biroulet L. Efficacy of herbal medicine (gegen qinlian decoction) on ulcerative colitis: a systematic review of randomized controlled trials. The clinical benefits of Chinese patent medicines against COVID-19 based on current evidence. Zhang D., Zhang B., Lv J.-T., Zhang X.-M., Lin Z.-J. CluePedia CluePedia: A ClueGO plugin for pathway insights using integrated experimental and in silico data CyNDEx-2 Core App: CyNDEx-2 is a user-friendly app for browsing, importing, and exporting networks to an NDEx server. Sophisticated UI gives links to GO, KEGG, etc. Globocan 2018: Cancer Fact Sheets-Colorectal Cancer. Bisogenet Retrieves interactions associated with input IDs. International Agency for Research on Cancer. Nature Reviews Gastroenterology & Hepatology. Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies. The study elucidated the "multiingredient, multitarget, and multipathway" mechanisms of GQD against CRC from a systemic perspective, indicating GQD to be a candidate therapy for CRC treatment. Functional analysis indicated that these targets were closely related to pathophysiological processes and pathways such as biosynthetic and metabolic processes of prostaglandins and prostanoids, cytokine and chemokine activities, and the IL-17, TNF, Toll-like receptor, and nuclear factor-kappa B (NF- κB) signaling pathways. A total of 212 GO terms and 6 KEGG pathways were enriched for target genes. Among these genes, CCNB1 and SPP1 were identified as crucial to the PPI network. Twenty corresponding target genes were screened out including PTGS2, CCNB1, and SPP1. One hundred and eighteen BCIs were determined to be effective on CRC, including quercetin, wogonin, and baicalein. Gene Ontology (GO) functional and the Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment analysis for target genes were then performed using the R package of clusterProfiler. A protein-protein interaction (PPI) network was subsequently constructed and analyzed with BisoGenet and CytoNCA plug-in in Cytoscape. The Cytoscape User Manual copyright is owned by The Cytoscape Consortium, and is made available under the same GPL license as Cytoscape itself: LGPL 2.1. The GQD-CRC ingredient-target pharmacology network was constructed and visualized using Cytoscape software. Target genes related to BCIs of GQD were then screened out. CRC-specific genes were obtained using the gene expression profile GSE110224 from the Gene Expression Omnibus (GEO) database. This study used network pharmacology analysis to investigate the mechanisms of GQD as a potential therapeutic approach against CRC.īioactive chemical ingredients (BCIs) of GQD were collected from the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database. A recent study demonstrated that GQD enhanced the effect of PD-1 blockade in colorectal cancer (CRC). Gegen Qinlian decoction (GQD) has been used to treat gastrointestinal diseases, such as diarrhea and ulcerative colitis (UC). ![]()
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